GENERAL SUMMARY/ OVERVIEW STATEMENT:
The job is as a Lab Manager in a biomedical research laboratory in the Division of Pulmonary and Critical Care Medicine at the Brigham and Women's Hospital (BWH).
This Lab Manager will lead the organization of the clinical and translational aspects of research in COVID-19, critical illness and lung inflammation. For clinical research, this position involves coordinating the research trainees and post-doctoral scientists who are using the STOP-COVID multi-center COVID-19 registry (looking at determinants of clinical outcomes); immunological biomarkers and outcomes in BWH COVID-19 patients; and development of a clinical registry of COVID-19 patients at Spaulding Rehab. Hospital (SRH, Long-term acute care). The lab manager will ensure compliance with IRB policies, in particular careful sample tracking and record keeping. This lab manager will also lead compliance with IACUC policies and organize the post-doctoral scientists involved in mouse model research. The lab manager will ensure biosafety protocols are compliant with the MGB IBC. The lab manager will also perform chemical and biochemical analysis of plasma and peripheral blood mononuclear cells from COVID-19 patients with comparison to other critical illness (e.g. sepsis, cardiac arrest) and inflammatory lung disease (e.g., inflammatory interstitial lung disease.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
- Work with COVID-19 clinical registry: In consultation with the P.I. and collaborators, the lab manager will coordinate (e.g., research trainees) and participate in on-going lab projects with COVID-19 clinical registries. The lab has access to the multi-center STOP-COVID clinical registry and is investigating determinants of clinical outcomes and also refine and then implement plans for a COVID-19 registry at Spaulding Rehab. Hospital, with collaborators at BWH and SRH.
- Design of translational experiments: In consultation with the lab P.I. and the scientific literature, the lab manager will design translational experiments including: ex vivo chemical and biochemical analysis of plasma from COVID-19 patients, in comparison to on-going lab research cohorts in non-COVID-19 critical illness (e.g., sepsis, cardiac arrest) and inflammatory interstitial lung disease.
- Execution of experiments: The lab manager will perform the designed experiments after approval by P.I.; and gain approval of the lab P.I. before significant expenditures in the labRecording data
- The lab manager will maintain a current electronic notebook in compliance with BWH policy, with a record of lab organization (including compliance with IRB, IACUC, IBC), experiments, results, methods and samples.
- Techniques: Techniques and experiments performed by the lab managers include: statistical analysis and recording of data; cell culture; ELISA; flow cytometry.
- Certifications: The lab manager will gain all necessary certifications for bench, in vivo and translational research (e.g., laboratory safety, training to be added to the IACUC-approved mouse protocol, human subject certification such as CITI necessary for IRB-approved human protocols).
- Human subjects research: Where qualified and added to the IRB-approved human protocol, the lab manager will enroll and obtain research samples from human subjects.
- Intra-mural meetings: The lab manager is expected to participate and present in virtual journal clubs, virtual work-in-progress conferences and virtual lab meetings.
- Extra-mural conferences and manuscripts: With approval of the lab P.I., the lab manager will prepare abstracts, posters and talks for extra-mural conferences as able. With approval of the lab P.I., the researcher will prepare manuscripts for publication.
- BS Required, MS preferred.
- Minimum of 5 years of progressively more responsible research work experience.
- Prior supervisory experience required.
SKILLS/ ABILITIES/ COMPETENCIES REQUIRED:
- Basic biochemical techniques (i.e., Western blot)
- Basic molecular biology techniques (i.e., Q-PCR, transformation / cloning of bacteria)
- Basic immunology techniques (i.e., flow cytometry)
- Cell culture
- Mouse breeding and basic mouse procedures (e.g., i.v. injection)
- Good organizational skills, detail oriented
- Basic statistical analysis of data, Computer literacy
- Teaching and mentoring skills for research traineess
- Excellent interpersonal skills, communication skills, professionalism